| Year | Won | Margin | Democratic | Republican | Total |
|---|---|---|---|---|---|
| 2024 | R | 921 | 8,064 | 9,050 | |
| 2020 | R | 1,059 | 7,933 | 9,138 | |
| 2016 | R | 999 | 7,166 | 8,371 | |
| 2012 | R | 1,643 | 6,133 | 7,936 | |
| 2008 | R | 1,962 | 6,249 | 8,419 | |
| 2004 | R | 2,846 | 5,379 | 8,338 | |
| 2000 | R | 2,747 | 4,122 | 6,992 | |
| 1996 | R | 2,709 | 2,766 | 6,109 | |
| 1992 | D | 3,910 | 3,393 | 8,072 | |
| 1988 | R | 3,378 | 3,646 | 7,052 | |
| 1984 | R | 2,879 | 3,527 | 6,428 | |
| 1980 | D | 4,595 | 2,489 | 7,221 | |
| 1976 | D | 3,734 | 1,969 | 5,839 | |
| 1972 | R | 443 | 4,177 | 4,681 | |
| 1968 | R | 358 | 617 | 5,544 | |
| 1964 | R | 977 | 1,934 | 2,911 | |
| 1960 | D | 1,222 | 536 | 2,427 | |
| 1956 | D | 1,577 | 516 | 2,170 | |
| 1952 | D | 1,595 | 679 | 2,274 | |
| 1948 | D | 711 | 98 | 1,884 | |
| 1944 | D | 1,412 | 296 | 1,708 | |
| 1940 | D | 1,463 | 159 | 1,630 | |
| 1936 | D | 1,619 | 115 | 1,744 | |
| 1932 | D | 1,636 | 112 | 1,754 | |
| 1928 | D | 965 | 585 | 1,550 | |
| 1924 | D | 1,181 | 279 | 1,460 | |
| 1920 | D | 841 | 387 | 1,249 | |
| 1916 | D | 1,031 | 175 | 1,225 | |
| 1912 | D | 701 | 65 | 904 | |
| 1908 | — | — | — | — | |
| 1904 | — | — | — | — | |
| 1900 | D | 704 | 123 | 828 | |
| 1896 | D | 851 | 67 | 921 | |
| 1892 | D | 612 | 58 | 745 | |
| 1888 | — | — | — | — | |
| 1884 | — | — | — | — | |
| 1880 | — | — | — | — | |
| 1876 | — | — | — | — |
Tishomingo sits in Mississippi's northeast corner along the Tennessee River, where a predominantly rural, non-Hispanic white population has delivered Republican presidential margins exceeding 75 points in recent cycles.
The unraveling was not abrupt. The Democratic margin in Tishomingo County peaked at eighty-seven points in 1932; it narrowed steadily over the late twentieth century. The 1996 election delivered the county to the Republican party for the first time in many years, by a margin of one points. By 2024, the margin had widened further.
The economic and demographic context is severe. Tishomingo County's median household income of $53,040 is among the lowest of any county in the United States; 18% of residents live below the federal poverty line. The county's voting pattern over the last decade is most similar to that of Lauderdale County and Alcorn County.