| Year | Won | Margin | Democratic | Republican | Total |
|---|---|---|---|---|---|
| 2024 | R | 1,757 | 7,986 | 9,844 | |
| 2020 | R | 1,664 | 7,657 | 9,456 | |
| 2016 | R | 1,520 | 6,908 | 8,740 | |
| 2012 | R | 2,184 | 5,669 | 7,987 | |
| 2008 | R | 3,005 | 5,527 | 8,647 | |
| 2004 | R | 2,621 | 5,583 | 8,247 | |
| 2000 | R | 2,085 | 4,667 | 6,903 | |
| 1996 | R | 2,517 | 3,427 | 6,781 | |
| 1992 | R | 2,525 | 3,205 | 7,252 | |
| 1988 | R | 2,136 | 3,836 | 5,986 | |
| 1984 | R | 1,837 | 4,493 | 6,330 | |
| 1980 | R | 2,416 | 5,053 | 7,689 | |
| 1976 | R | 2,801 | 4,086 | 6,918 | |
| 1972 | R | 1,953 | 4,736 | 6,689 | |
| 1968 | R | 1,958 | 3,858 | 6,278 | |
| 1964 | D | 3,456 | 2,837 | 6,293 | |
| 1960 | R | 2,991 | 3,886 | 6,877 | |
| 1956 | R | 2,346 | 4,400 | 6,746 | |
| 1952 | R | 2,324 | 4,633 | 6,960 | |
| 1948 | R | 2,133 | 2,903 | 5,043 | |
| 1944 | R | 2,014 | 4,207 | 6,226 | |
| 1940 | R | 2,354 | 4,656 | 7,019 | |
| 1936 | R | 3,098 | 3,382 | 6,606 | |
| 1932 | D | 3,502 | 2,396 | 5,917 | |
| 1928 | R | 2,591 | 2,648 | 5,245 | |
| 1924 | R | 6,568 | 7,280 | 15,236 | |
| 1920 | R | 1,504 | 3,652 | 5,181 | |
| 1916 | R | 1,396 | 1,988 | 3,404 | |
| 1912 | R | 1,564 | 1,735 | 3,411 | |
| 1908 | R | 1,569 | 1,775 | 3,379 | |
| 1904 | R | 1,522 | 1,733 | 3,304 | |
| 1900 | R | 1,660 | 1,681 | 3,372 | |
| 1896 | R | 1,450 | 1,522 | 3,010 | |
| 1892 | D | 1,464 | 1,297 | 2,766 | |
| 1888 | — | — | — | — | |
| 1884 | — | — | — | — | |
| 1880 | — | — | — | — | |
| 1876 | — | — | — | — |
Perry County, nestled along the Mississippi River in southeast Missouri, recorded a 63-point Republican presidential margin in 2024 — a spread that reflects the broader realignment of small, majority-white rural counties across the state over the past two decades.
The Republican margin in Perry County reached its widest at sixty-three points in 2020. The margin in 2024 was sixty-three points, in line with the county's deep historical pattern.
Perry County's loyalty is rooted in its place. Median household income of $62,981, a 94% non-Hispanic-white share, and a population of 18,976 together describe a community whose political habits are deeply settled. The county's voting pattern over the last decade is most similar to that of Douglas County and Edwards County.