| Year | Won | Margin | Democratic | Republican | Total |
|---|---|---|---|---|---|
| 2024 | R | 1,270 | 6,515 | 7,825 | |
| 2020 | R | 1,494 | 6,567 | 8,118 | |
| 2016 | R | 1,163 | 5,519 | 6,844 | |
| 2012 | R | 1,467 | 5,122 | 6,638 | |
| 2008 | R | 1,716 | 4,888 | 6,626 | |
| 2004 | R | 1,610 | 5,100 | 6,732 | |
| 2000 | R | 1,570 | 4,541 | 6,183 | |
| 1996 | R | 2,074 | 3,577 | 6,164 | |
| 1992 | R | 2,127 | 3,238 | 6,730 | |
| 1988 | R | 2,579 | 3,628 | 6,255 | |
| 1984 | R | 1,882 | 4,401 | 6,292 | |
| 1980 | R | 2,044 | 3,450 | 5,580 | |
| 1976 | R | 2,540 | 2,754 | 5,327 | |
| 1972 | R | 1,357 | 3,755 | 5,147 | |
| 1968 | R | 1,871 | 2,589 | 5,244 | |
| 1964 | D | 3,286 | 2,283 | 5,573 | |
| 1960 | R | 2,253 | 2,763 | 5,029 | |
| 1956 | R | 1,435 | 3,401 | 4,849 | |
| 1952 | R | 1,934 | 4,075 | 6,018 | |
| 1948 | D | 1,808 | 1,612 | 3,647 | |
| 1944 | D | 1,884 | 1,879 | 4,187 | |
| 1940 | D | 2,056 | 1,735 | 3,791 | |
| 1936 | D | 1,977 | 616 | 2,602 | |
| 1932 | D | 3,206 | 309 | 3,521 | |
| 1928 | D | 1,594 | 1,142 | 2,741 | |
| 1924 | D | 4,708 | 712 | 5,805 | |
| 1920 | R | 971 | 1,277 | 3,309 | |
| 1916 | R | 1,056 | 1,068 | 2,147 | |
| 1912 | D | 1,081 | 219 | 1,494 | |
| 1908 | — | — | — | — | |
| 1904 | — | — | — | — | |
| 1900 | — | — | — | — | |
| 1896 | — | — | — | — | |
| 1892 | — | — | — | — | |
| 1888 | — | — | — | — | |
| 1884 | — | — | — | — | |
| 1880 | — | — | — | — | |
| 1876 | — | — | — | — |
DeWitt County's 2024 presidential margin of R+67 places it among the most lopsided rural counties in the state, a pattern consistent with its small-town, agriculture-rooted demographic profile along the Guadalupe River corridor.
The Democratic margin in DeWitt County peaked at eighty-two points in 1932. By 1968 the county had flipped, voting Republican for the first time in many years. The 2024 margin was sixty-seven points, the most Republican-leaning result in the county's modern history.
The economic context is the key. DeWitt County's median household income of $63,730 sits well below state and national norms, and 18% of residents live below the federal poverty line. The shift here is part of a broader realignment of working-class places across the country. The county's voting pattern over the last decade is most similar to that of Yuma County and Phillips County.