| Year | Won | Margin | Democratic | Republican | Total |
|---|---|---|---|---|---|
| 2024 | R | 29,573 | 54,691 | 85,350 | |
| 2020 | R | 28,805 | 47,553 | 77,758 | |
| 2016 | R | 18,391 | 36,632 | 58,123 | |
| 2012 | R | 15,744 | 33,117 | 49,626 | |
| 2008 | R | 16,156 | 30,869 | 47,461 | |
| 2004 | R | 10,290 | 28,208 | 38,752 | |
| 2000 | R | 8,311 | 21,499 | 30,567 | |
| 1996 | R | 8,079 | 14,254 | 24,403 | |
| 1992 | R | 6,567 | 10,818 | 23,120 | |
| 1988 | R | 7,111 | 13,265 | 20,609 | |
| 1984 | R | 5,060 | 14,382 | 19,488 | |
| 1980 | R | 5,049 | 9,901 | 15,428 | |
| 1976 | R | 6,054 | 6,766 | 12,935 | |
| 1972 | R | 3,404 | 8,287 | 11,698 | |
| 1968 | R | 3,529 | 4,332 | 9,102 | |
| 1964 | D | 4,568 | 2,731 | 7,308 | |
| 1960 | R | 3,116 | 3,657 | 6,787 | |
| 1956 | R | 2,099 | 4,296 | 6,425 | |
| 1952 | R | 2,330 | 4,396 | 6,740 | |
| 1948 | R | 2,119 | 2,502 | 4,908 | |
| 1944 | R | 1,583 | 2,556 | 4,343 | |
| 1940 | R | 2,182 | 2,473 | 4,661 | |
| 1936 | D | 2,962 | 1,266 | 4,237 | |
| 1932 | D | 3,751 | 691 | 4,451 | |
| 1928 | D | 1,872 | 1,442 | 3,318 | |
| 1924 | R | 831 | 1,657 | 4,089 | |
| 1920 | R | 560 | 1,839 | 3,232 | |
| 1916 | R | 830 | 1,812 | 2,650 | |
| 1912 | D | 1,128 | 1,065 | 2,754 | |
| 1908 | — | — | — | — | |
| 1904 | — | — | — | — | |
| 1900 | — | — | — | — | |
| 1896 | — | — | — | — | |
| 1892 | — | — | — | — | |
| 1888 | — | — | — | — | |
| 1884 | — | — | — | — | |
| 1880 | — | — | — | — | |
| 1876 | — | — | — | — |
Guadalupe County sits at the northeastern edge of the San Antonio metro, where rapid suburban growth has not eroded a Republican presidential margin that has held above 25 points for over a decade.
The Republican margin in Guadalupe County reached its widest at forty-eight points in 1984. The margin in 2024 was twenty-nine points, in line with the county's deep historical pattern.
Guadalupe County's loyalty is rooted in its place. Median household income of $92,375, a 55% non-Hispanic-white share, and a population of 183,642 together describe a community whose political habits are deeply settled. The county's voting pattern over the last decade is most similar to that of Rockwall County and Lubbock County.
