| Year | Won | Margin | Democratic | Republican | Total |
|---|---|---|---|---|---|
| 2024 | D | 39,008 | 32,247 | 72,261 | |
| 2020 | D | 37,846 | 28,684 | 67,884 | |
| 2016 | D | 32,406 | 26,378 | 63,674 | |
| 2012 | D | 36,693 | 25,751 | 63,462 | |
| 2008 | D | 38,524 | 23,701 | 63,218 | |
| 2004 | D | 33,170 | 28,289 | 62,136 | |
| 2000 | D | 28,455 | 24,327 | 55,559 | |
| 1996 | D | 23,647 | 16,482 | 46,001 | |
| 1992 | D | 22,838 | 18,891 | 52,273 | |
| 1988 | D | 22,204 | 21,548 | 44,066 | |
| 1984 | R | 17,787 | 25,721 | 43,769 | |
| 1980 | R | 17,304 | 23,427 | 45,285 | |
| 1976 | R | 16,674 | 24,188 | 41,659 | |
| 1972 | R | 12,152 | 21,992 | 34,746 | |
| 1968 | R | 11,570 | 17,433 | 31,267 | |
| 1964 | D | 16,625 | 13,135 | 29,803 | |
| 1960 | R | 14,310 | 18,319 | 32,665 | |
| 1956 | R | 11,258 | 18,264 | 29,622 | |
| 1952 | R | 11,808 | 19,271 | 31,132 | |
| 1948 | D | 12,345 | 10,525 | 23,260 | |
| 1944 | R | 12,247 | 12,784 | 25,103 | |
| 1940 | R | 13,079 | 13,711 | 26,924 | |
| 1936 | D | 14,455 | 7,558 | 22,840 | |
| 1932 | D | 12,919 | 7,686 | 20,805 | |
| 1928 | R | 8,877 | 11,321 | 20,295 | |
| 1924 | R | 1,252 | 5,733 | 17,647 | |
| 1920 | R | 2,588 | 10,067 | 13,611 | |
| 1916 | D | 4,123 | 3,597 | 8,106 | |
| 1912 | D | 4,263 | 2,272 | 8,033 | |
| 1908 | R | 4,054 | 4,382 | 8,737 | |
| 1904 | R | 3,089 | 5,506 | 8,915 | |
| 1900 | R | 3,609 | 5,324 | 9,141 | |
| 1896 | R | 3,058 | 6,297 | 9,751 | |
| 1892 | D | 3,810 | 3,693 | 8,613 | |
| 1888 | — | — | — | — | |
| 1884 | — | — | — | — | |
| 1880 | — | — | — | — | |
| 1876 | — | — | — | — |
Home to the University of Wisconsin–La Crosse and a regional medical hub, La Crosse County has voted Democratic in every presidential race since 2000, with its 2024 margin of D+9.4 reflecting a consistent urban-academic lean along the Mississippi.
The Democratic margin in La Crosse County reached its widest at thirty points in 1936. The margin in 2024 was nine points — still decisive.
La Crosse County's loyalty is rooted in its place. Median household income of $73,013, a 88% non-Hispanic-white share, and a population of 120,488 together describe a community whose political habits are deeply settled. The county's voting pattern over the last decade is most similar to that of Grand Isle County and Iowa County.
