| Year | Won | Margin | Democratic | Republican | Total |
|---|---|---|---|---|---|
| 2024 | R | 1,895 | 2,549 | 4,456 | |
| 2020 | R | 2,044 | 2,370 | 4,444 | |
| 2016 | R | 1,971 | 2,035 | 4,059 | |
| 2012 | D | 2,270 | 1,907 | 4,205 | |
| 2008 | D | 2,402 | 2,087 | 4,519 | |
| 2004 | D | 2,220 | 2,112 | 4,369 | |
| 2000 | D | 1,977 | 1,570 | 3,615 | |
| 1996 | D | 1,927 | 958 | 3,110 | |
| 1992 | D | 2,097 | 853 | 3,392 | |
| 1988 | D | 1,730 | 1,261 | 3,005 | |
| 1984 | D | 1,755 | 1,143 | 2,898 | |
| 1980 | D | 2,213 | 747 | 2,980 | |
| 1976 | D | 2,515 | 513 | 3,028 | |
| 1972 | R | 1,113 | 1,363 | 2,476 | |
| 1968 | D | 812 | 336 | 2,315 | |
| 1964 | R | 786 | 1,178 | 1,964 | |
| 1960 | D | 845 | 263 | 1,108 | |
| 1956 | D | 1,002 | 168 | 1,170 | |
| 1952 | D | 1,080 | 191 | 1,271 | |
| 1948 | D | 359 | 52 | 815 | |
| 1944 | D | 457 | 170 | 627 | |
| 1940 | D | 723 | 91 | 814 | |
| 1936 | D | 491 | 57 | 549 | |
| 1932 | D | 646 | 15 | 664 | |
| 1928 | D | 571 | 74 | 645 | |
| 1924 | D | 417 | 39 | 486 | |
| 1920 | D | 273 | 44 | 317 | |
| 1916 | D | 365 | 20 | 400 | |
| 1912 | D | 307 | 3 | 323 | |
| 1908 | D | 301 | 73 | 395 | |
| 1904 | D | 378 | 30 | 427 | |
| 1900 | D | 321 | 56 | 379 | |
| 1896 | D | 397 | 128 | 525 | |
| 1892 | D | 435 | 235 | 1,018 | |
| 1888 | — | — | — | — | |
| 1884 | — | — | — | — | |
| 1880 | — | — | — | — | |
| 1876 | — | — | — | — |
Twiggs sits along the fall line separating Georgia's Piedmont and Coastal Plain, with a population split nearly evenly between Black and white residents — a demographic mix that has kept presidential margins closer here than in surrounding rural counties for decades.
The Democratic margin in Twiggs County has rarely exceeded ninety-five points in modern history; the Republican margin has rarely exceeded twenty points. 2024 delivered the county to the Republican candidate by fifteen points.
Twiggs County's demographics resemble the country more than they resemble most counties. A 55% non-Hispanic-white share, a 18% poverty rate, and a median household income of $56,324 — all within the broad national range. The county's voting pattern over the last decade is most similar to that of Dooly County and McCormick County.
