| Year | Won | Margin | Democratic | Republican | Total |
|---|---|---|---|---|---|
| 2024 | R | 27,706 | 32,615 | 61,140 | |
| 2020 | R | 31,153 | 32,615 | 64,510 | |
| 2016 | R | 26,710 | 29,573 | 57,931 | |
| 2012 | R | 28,614 | 28,961 | 58,122 | |
| 2008 | R | 28,012 | 29,861 | 58,373 | |
| 2004 | R | 21,442 | 27,689 | 49,545 | |
| 2000 | R | 17,157 | 23,678 | 41,437 | |
| 1996 | R | 15,804 | 18,490 | 36,070 | |
| 1992 | R | 15,569 | 19,802 | 39,003 | |
| 1988 | R | 12,531 | 19,490 | 32,214 | |
| 1984 | R | 14,639 | 22,753 | 37,600 | |
| 1980 | R | 16,391 | 17,069 | 34,011 | |
| 1976 | D | 16,294 | 13,539 | 29,904 | |
| 1972 | R | 9,455 | 18,106 | 27,726 | |
| 1968 | R | 8,079 | 8,917 | 24,638 | |
| 1964 | R | 7,157 | 10,346 | 17,503 | |
| 1960 | D | 6,090 | 5,815 | 11,906 | |
| 1956 | D | 3,463 | 1,855 | 9,765 | |
| 1952 | D | 5,340 | 5,236 | 10,576 | |
| 1948 | D | 1,189 | 192 | 5,110 | |
| 1944 | D | 2,822 | 128 | 3,212 | |
| 1940 | D | 2,597 | 95 | 2,692 | |
| 1936 | D | 4,194 | 0 | 4,219 | |
| 1932 | D | 3,195 | 0 | 3,226 | |
| 1928 | D | 1,672 | 93 | 1,765 | |
| 1924 | D | 1,217 | 32 | 1,301 | |
| 1920 | D | 1,763 | 79 | 1,842 | |
| 1916 | D | 1,912 | 26 | 1,938 | |
| 1912 | D | 1,496 | 0 | 1,573 | |
| 1908 | D | 1,460 | 28 | 1,498 | |
| 1904 | D | 1,406 | 31 | 1,437 | |
| 1900 | D | 1,290 | 74 | 1,364 | |
| 1896 | D | 1,530 | 136 | 1,701 | |
| 1892 | D | 1,609 | 293 | 1,902 | |
| 1888 | — | — | — | — | |
| 1884 | — | — | — | — | |
| 1880 | — | — | — | — | |
| 1876 | — | — | — | — |
Florence anchors the Pee Dee region and functions as a regional service hub, producing presidential margins closer than most surrounding counties while reflecting South Carolina's broader shift toward Republican-leaning results over the past two decades.
The Democratic margin in Florence County has rarely exceeded ninety-nine points in modern history; the Republican margin has rarely exceeded thirty-one points. 2024 delivered the county to the Republican candidate by eight points.
Florence County's demographics resemble the country more than they resemble most counties. A 50% non-Hispanic-white share, a 19% poverty rate, and a median household income of $58,305 — all within the broad national range. The county's voting pattern over the last decade is most similar to that of Lancaster County and Lowndes County.
