| Year | Won | Margin | Democratic | Republican | Total |
|---|---|---|---|---|---|
| 2024 | D | 5,420 | 1,243 | 6,730 | |
| 2020 | D | 6,588 | 1,369 | 8,115 | |
| 2016 | D | 6,689 | 1,309 | 8,076 | |
| 2012 | D | 7,812 | 1,435 | 9,288 | |
| 2008 | D | 7,765 | 1,714 | 9,543 | |
| 2004 | D | 6,366 | 1,961 | 8,383 | |
| 2000 | D | 5,447 | 1,937 | 7,422 | |
| 1996 | D | 4,720 | 1,536 | 6,411 | |
| 1992 | D | 4,092 | 1,694 | 6,014 | |
| 1988 | D | 5,350 | 2,737 | 8,126 | |
| 1984 | D | 5,641 | 3,102 | 8,753 | |
| 1980 | D | 5,463 | 2,693 | 8,336 | |
| 1976 | D | 4,616 | 2,438 | 7,203 | |
| 1972 | D | 3,459 | 3,158 | 6,686 | |
| 1968 | D | 3,881 | 520 | 7,409 | |
| 1964 | R | 110 | 3,115 | 3,225 | |
| 1960 | D | 628 | 455 | 2,567 | |
| 1956 | D | 872 | 215 | 2,139 | |
| 1952 | D | 1,423 | 1,305 | 2,728 | |
| 1948 | D | 61 | 24 | 2,224 | |
| 1944 | D | 1,954 | 122 | 2,076 | |
| 1940 | D | 2,041 | 37 | 2,078 | |
| 1936 | D | 1,885 | 12 | 1,897 | |
| 1932 | D | 1,799 | 45 | 1,852 | |
| 1928 | D | 2,004 | 134 | 2,138 | |
| 1924 | D | 1,173 | 92 | 1,265 | |
| 1920 | D | 917 | 69 | 1,001 | |
| 1916 | D | 1,070 | 21 | 1,105 | |
| 1912 | D | 936 | 5 | 982 | |
| 1908 | — | — | — | — | |
| 1904 | — | — | — | — | |
| 1900 | D | 900 | 39 | 953 | |
| 1896 | D | 1,010 | 74 | 1,095 | |
| 1892 | D | 641 | 23 | 862 | |
| 1888 | — | — | — | — | |
| 1884 | — | — | — | — | |
| 1880 | — | — | — | — | |
| 1876 | — | — | — | — |
Holmes County, anchored by the Delta town of Lexington, posts presidential margins exceeding 60 points Democratic — driven by a population that is roughly 80% Black, a demographic legacy of the Delta's plantation-era labor geography.
The unraveling was not abrupt. The Democratic margin in Holmes County peaked at ninety-nine points in 1936; it narrowed steadily over the late twentieth century. The 1968 election delivered the county to the Republican party for the first time in many years, by a margin of forty-five points. By 2024, the margin had widened further.
The economic and demographic context is severe. Holmes County's median household income of $32,538 is among the lowest of any county in the United States; 36% of residents live below the federal poverty line. The county's voting pattern over the last decade is most similar to that of Petersburg city and Alameda County.